only monoclonal Tls, few patients. We are looking abroad, at the Scotte cured in 40 – Corriere di Siena
Overall they serve about 400 patients, in the various centers that are working on this topic in the country, to arrive at data that can lead to an evaluation, and hopefully an approval, for the work that for some time the Discovery of monoclonal antibodies (Mad) Lab of Life sciences in Tuscany, coordinator by the professor Rino Rappuoli, is carrying out on the drug of the mainly monoclonal. That number has not yet arrived. And in fact, in Repubblica, the president of Tls Fabrizio Landi declared that part of the work could now be carried out abroad. The work is now in his phases 2 and 3, the final ones. However, there was clearly a shift in times to what had been the rosy expectations of the eve. In fact, it was initially assumed that the monoclonals of Tls claim to be approved and therefore used since spring. Then we talked about July and then October as the final timing. Now we have arrived in October but the work continues.
With this in mind, it is necessary to evaluate and consider what was the position taken by the president of the Tuscany Region, Eugenio Giani. An acceleration of operations is now required. Giani turns not so much to “his” people, to the Tuscans who are doing the work, as to those who are doing it in other national territories. Because to arrive at an effective evaluation of the studies they must treat 400 patients in a large and vast geographical area, practically throughout the country. And instead, as Giani said, “70% of the work up to now has been done in Tuscany. I am making the appeal to the Regions because this is an antibody made in Italy, which will therefore be important as unlike vaccination it is our tool. The agreement with Tls was made by the Tuscany Region but above all by the Ministry of Health ”. In Tuscany, therefore, says Giani, up to now 70% of the work has been completed. To date at the Scotte hospital They were treated over 140 patients with monoclonals, of which about 100 with the drugs approved by AIFA and about 40 with the Tls experiments. As for the Tls experiments, the number is in line with what was established at the beginning of the programming and will be incremental in the coming days.
There are three i Tuscan centers where does it come with the testing of Tls monoclonals: in addition to Sheets of Siena the work is carried out in Florence and Pisa. And the numbers of these centers are significant. They are also in the center of Parma, which together with the Tuscan ones was one of the first to be. However, the same is not happening in other realities. There are a total of 11 centers in the country that are working: Rome, Piacenza, Foggia, Siena, Vercelli, Verona, Milan, Parma, Pisa, Florence, Naples. There are various issues that are being addressed at this stage. Among these, also the stringent rules at the basis of the work. A patient must give his availability and acceptance to the trial no later than 72 hours from the moment he comes to knowledge of Covid positivity. Three days may seem like a long time, but it may not be for those who suddenly learn that they have contracted a virus that has been killing victims all over the world for almost two years now. In addition, paradoxically, the decline in infections in the country is the number of potential people who can undergo the experimentation. Patient enrollment is therefore not easy Right now.
The governor Giani he returns to talk about the issue to the Corriere di Siena: “My appeal is addressed to various Italian regions. Tuscany has done its utmost, there we await commitment on the subject also from other territories. I will address the issue with other regional presidents, the intent is that there is greater awareness throughout the country. I remember that in October of last year I was with Professor Rino Rappuoli when the authorization for the experimentation arrived. I thought that after a year the work could have already been completed. Now you need sensitivity in other areas of the country as well ”.