Toulouse. People infected with covid-19 and vaccinated are protected longer
Through Lucie Fraissé
Published on
Having contracted covid-19 and having received one dose of the vaccine would protect the risk of contracting the virus longer than having received two doses of the vaccine, without ever having been infected. This is the result of a study carried out by the virology department of Toulouse University Hospital, which has just been published in the journal Clinical infectious disease.
A study on the nursing staff of the CHU
Since the start of the pandemic, the virology laboratory of Toulouse University Hospital hospital caregivers costume. The initial study involved 8,750 voluntary caregivers. A study published last September, based on the serological monitoring over time of caregivers, had in particular made it possible to establish protective antibody thresholds against infection or reinfection with Sars-Cov-2.
“Once we established those protection thresholds, we were told, ‘Okay but how long does the protection last? ‘, Explain Chloe Dimeglio, biostatistician at Toulouse University Hospital. This new study answers that question. “
Protected twice as long
145 caregivers were thus followed for 143 days. Some had contracted the virus and received one dose of Pfizer vaccine, others had not been infected and had been vaccinated with two doses of Pfizer.
“On average, the vaccinated are protected for 309 days, describes the virologist of the Toulouse University Hospital. While those who were infected and then vaccinated are protected on average for 714 days. The vaccinated infected are therefore protected twice as long.
Data related to the alpha variant
As vaccinodromes reopen and the race for the booster dose is on, can these data pay off the vaccine strategy? And of give priority to people who have never had covid-19 for this famous third dose?
Chloé Dimeglio nuance.
“We have this study on the reinfection data we had. And the caregivers had been infected with the alpha variant. We know that the delta strain escapes vaccination more than the alpha strain. Let’s say that the study gives directions, but it’s not to be taken literally, knowing that delta dominates, and that omicron is coming. “
The data collected via this Toulouse study in any case validates the timing of the booster dose. “Doing a booster within 5-6 months after vaccination is rather consistent,” says Chloé Dimeglio.
The virology department of the Toulouse University Hospital is seeking to conduct a similar study, with the Delta strain. “The concern is that we have fewer caregivers infected with delta, which is rather reassuring: the vaccination worked. But in terms of statistics, we do not have enough events for the results to be achieved. “
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