San Marino. “Booster dose: the assurances of the ISS”
“We are living in a delicate phase and the vaccination campaign for the administration of the booster dose or” booster “to counter the effects of the Covid-19 pandemic deserves reassurance towards the citizens. The Institute for Social Security therefore wishes to do a little ‘of clarity also towards those who try to undermine the virtuous path undertaken by San Marino.
For this reason, the ISS Vaccines Commission intends to clarify some aspects “.
This is what we read in a press release. “Safety of mRNA vaccines: There are over 7 billion vaccine administrations against Covid in the world and 3 billion people have completed the primary vaccination course, in the majority of cases using mRNA vaccines. We believe that the data produced in one year on these vaccines have been sufficient for some vaccines a definitive authorization, drawing up a reasonable safety profile.
Heterologous vaccination: To those who claim that there are no studies on heterologous vaccination, nor studies on the possible negative effects after the third dose of mRNA vaccine, this must not be true. Studies on heterologous vaccination are numerous today and agree in underlining that heterologous vaccination is not only as safe as the homologous one, but induces a broader and more effective immune response (both antibody and cellular), especially against the Delta variant. These studies were considered sufficient to consider heterologous vaccination by AIFA effective and safe and applicable both in Europe and in the USA.
Furthermore, San Marino is not the only country in Europe to authorize the vaccine mix approach in the anti-Covid vaccination campaign. For example, Denmark, Finland, France, Germany, Sweden, Norway, Spain and Italy also recommend a second dose of Pfizer and Moderna vaccines for subjects who have received a first dose of AstraZeneca-manufactured (viral vector) vaccine.
Third dose in Pfizer vaccinates: Data from Israel, which proposed the third dose of the vaccine in all age groups after 5 months of completing the two-dose primary vaccination (as well as data published by the CDC in Atlanta on side effects of the third dose of mRNA vaccine in the USA), have confirmed a safety profile for the additional dose of Pfizer that is entirely comparable to that observed at the second dose.
Utility of serological tests: Serological tests should not be carried out to decide whether to recall the vaccination against Covid, as the available tests have not been designed to quantify the immune response and its efficiency, but only to measure the.
We know that the protective ones are the neutralizing ones, but we do not know if and how much these are expressed by the tests on the market. Furthermore, it has not been defined with certainty to guarantee how safe a protection is. The regulatory bodies and the Scientific Technical Committee in Italy are expressed all against the dosage of the beginnings as an indicator to perform the booster dose of the vaccine.
The third dose should be given in all people, using an mRNA vaccine unless there are contraindications to the administration of this product in the vaccine used for the primary vaccination.
Having made these considerations, the Institute for Social Security intends to clarify that over time, the third dose of vaccine will have to be administered to almost all adults, while following a program that first protects the most vulnerable people. In fact, the program launched in San Marino follows this principle “.
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