Through Lucie Fraissé
Vaccination against covid-19 provides better protection than natural infection alone. This is one of the lessons of a study carried out by Toulouse University Hospital, published on September 21, 2021 in the scientific journal “Infection diary”.
A study carried out on the serologies of caregivers
The study was conducted among 8,758 hospital caregivers by the virology, occupational health and infectious diseases departments, between June 2020 and July 2021.
The work of researchers from Toulouse University Hospital allowed the establishment of protective antibody thresholds against infection or reinfection with SARS-Cov-2. And to show that the protection offered by vaccination was better than that obtained by people who contracted covid-19.
An essential discovery for vaccine strategies
“After two doses of vaccines, 15 days after their second dose, no individual had a low concentration of total antibodies, they were not all protected at least at 89.3%, indicates the Toulouse University Hospital in a press release. In contrast, 79.3% of people previously infected but not vaccinated had a level of protection against reinfection of only 12.4%. “
Beyond this discovery, the update of the thresholds of protective antibodies against infection or reinfection with Covid-19 should make it possible to better define future vaccine and therapeutic strategies.
“The definition of these protection thresholds in connection with the antibody response after a vaccination or a natural infection is essential today to refine the vaccine (3rd dose) or therapeutic (use of monoclonal antibodies) protocols, in particular for immunocompromised people responding poorly to conventional vaccination schedules, ”says Chloé Dimeglio, biostatistician at the virology laboratory of Toulouse University Hospital.
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